If this is the Lake Nipissing up near North Bay, Ontario, then I would say it is a large lake. That can get rough quick. However if you're at one of the resorts at the east end, near or in Callander Bay, you can often find sheltered areas close to camp. I've fished that area extensively over the years. The West End is likely the same story but I cannot speak to it. As for boat experience, most operators up there will be willing to help you out and show you areas to fish that are close by. Be sure to get familiar with the slot size and restrictions if you're fishing walleye - it is pretty discouraging if you're looking to keep fish. If catch and release is your thing, then you should enjoy the lake. Lots of different fish in there. Walleye is by far the most popular, but you can find perch, bass, pike, musky, etc....