I think I am the most opinionated person in regards to Cassadaga, so I figured I should throw in my two cents...
If it was not a holiday weekend, I would tell you not to go to Cassadaga. Sure, it is an easy lake to get numbers on, but a probable chance of a decent-sized fish is not there. There have been guys that have caught fish in the mid to upper 40s on that lake, but most are low 30s. I want that chance at a 50 no matter where I am fishing. Also, every trip to Chautauqua is a learning experience with so much water to try out and learn. Cassadaga gets boring quickly due to its size. However...with a 12' boat, the forecast (as Adam mentioned), and that there will be gobs and gobs of pleasure boaters swamping every fisherman on Chautauqua this weekend, it is not a bad weekend to voyage out to Cassadaga (it hurts me to even write that. haha)
I knew a couple guys a few years back that started their weekend on Chautauqua. They fished the early morning bite and got off the water when they saw all the pleasure boaters start flooding the lake. At that point, they pulled their boat and traveled over to Cassadaga. Since you are starting your trip in Jamestown, this might be a nice move for you? You would get to experience two different lakes!