Guess depends on what your looking to do with it. The regular 300 win mag will be a lot cheaper to keep ammo in. I have a 300 mag that I reload Berger VLD handloads for, my brother in-law reloads Berger's for a 300 ultra mag he is spending alot more per round. As for your original question it will kill anything that walks as far as you can shoot it, but so will alot of smaller more economical rounds. If I was going to set up a long range gun it wouldn't be a short action. Sean